ABC膜转运蛋白及其调控在肿瘤耐药和解毒新机制中的研究进展

王超,方平飞,蔡骅琳

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (22) : 1961-1965.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (22) : 1961-1965. DOI: 10.11669/cpj.2017.22.001
综述

ABC膜转运蛋白及其调控在肿瘤耐药和解毒新机制中的研究进展

  • 王超1,方平飞1,2*,蔡骅琳1,2
作者信息 +

Research Progress of ABC Membrane Transporters and Their Regulation in Tumor Drug Resistance and New Mechanism of Detoxification

  • WANG Chao1, FANG Ping-fei1,2*,CAI Hua-lin1,2
Author information +
文章历史 +

摘要

肿瘤细胞的多药耐药(MDR)是导致化疗失败的主要原因,而ABC膜转运蛋白的过度表达是多药耐药产生的重要因素。通过下调肿瘤细胞药物转运蛋白的表达来逆转多药耐药的研究已经取得了显著性进展;从肿瘤耐药机制得到启发,通过上调药物转运蛋白的表达加速毒物的外排正受到越来越多的关注。笔者总结了近年膜转运蛋白在肿瘤耐药机制研究中的进展,以此为基础进行的解毒新机制研究。

Abstract

Multidrug resistance of tumor cells is a material cause of chemotherapy failure, and the overexpression of adenosine triphosphate-binding cassette(ABC) membrane transporters is an important factor in multidrug resistance. Significant progress has been made in reversing multidrug resistance by reducing the expression of drug transporters on tumor cells; inspired by the mechanism of multidrug resistance,speeding up the efflux of poisons by increasing the expression of drug transporters is attracting more and more attention. In this review, We summarized the research progress on mechanism of membrane transp-orters in drug resistance in recent years, and new mechanism of detoxification based on these theories.

关键词

解毒新机制 / 多药耐药 / 甘草 / 外排转运体 / 药物代谢酶

Key words

new mechanism of detoxification / multidrug resistance / licorice / efflux transporters / drug metabolic enzymes

引用本文

导出引用
王超,方平飞,蔡骅琳. ABC膜转运蛋白及其调控在肿瘤耐药和解毒新机制中的研究进展[J]. 中国药学杂志, 2017, 52(22): 1961-1965 https://doi.org/10.11669/cpj.2017.22.001
WANG Chao, FANG Ping-fei,CAI Hua-lin. Research Progress of ABC Membrane Transporters and Their Regulation in Tumor Drug Resistance and New Mechanism of Detoxification[J]. Chinese Pharmaceutical Journal, 2017, 52(22): 1961-1965 https://doi.org/10.11669/cpj.2017.22.001
中图分类号: R965   

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基金

国家自然科学基金资助项目(81473411,81573686)
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